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Abstract #1933

MRI Relaxometry Correlation against Iron in Alzheimers Disease

Christos Michaelides 1 , David J Lythgoe 1 , Harold G Parkes 2 , Claire Troakes 3 , Istvan Bodi 4 , Tina Geraki 5 , Amy H Herlihy 6 , and Po-Wah So 1

1 Department of Neuroimaging, Institute of Psychiatry, King's College London, London, London, United Kingdom, 2 CR-UK Clinical MR Research Group, Institute of Cancer Research, Sutton, Surrey, United Kingdom, 3 MRC London Neurodegenerative Diseases Brain Bank, Department of Clinical Neuroscience, Institute of Psychiatry, Kings College London, London, United Kingdom, 4 Clinical Neuropathology & London Neurodegenerative Diseases Brain Bank, King's College London, Kings College Hospital, London, United Kingdom, 5 Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, United Kingdom, 6 Agilent Technologies, Yarnton, Oxfordshire, United Kingdom

Iron dysregulation may be a contributing factor to neuronal cell death in Alzheimers disease. MR relaxometry measurements in fixed post-mortem human AD and control samples were correlated with direct iron assessment by synchrotron-radiation X-ray fluorescence mapping. AD did not affect iron concentrations or relaxometry. Whilst R2 and R2* correlated with iron, R1 correlated less well, potentially due to significant effects from fixation time. Increased iron in white compared to grey matter is consistent with elevated iron concentrations within white matter myelin. Our results support R2 and R2* relaxometry in non-invasive assessment of brain iron.

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