Abstract #1936
Amyloid plaques detection by MRI: comparison of five mouse models of amyloidosis
Matthias Vandesquille 1,2 , Chrystelle Po 1,2 , Mathieu Santin 1,3 , Emmanuel Comoy 4 , and Marc Dhenain 1
1
MIRCen, CEA, Fontenay-aux-Roses, France,
2
Institut
Pasteur, Paris, France,
3
ICM,
Hpital de la Piti Salptrire, Paris, France,
4
SEPIA,
CEA, Fontenay-aux-Roses, France
Amyloid plaques are one of the hallmarks of Alzheimers
disease and numerous mouse models of amyloidosis have
been developed to study the pathology. In APP
sl
/PS1
M146L
mice
amyloid plaques can be detected by
in
vivo
MRI
thanks to gadolinium-staining procedure, a method based
on the intravenous or intracerebroventricular
administration of gadolinium contrast agent to the mice.
The present work evaluated gadolinium-staining procedure
to compare the
in
vivo
and
ex
vivo
MRI
detection of amyloid plaques in five different mouse
strains developing amyloidosis. Depending on the strain,
the number, the size and the contrast of the plaques are
highly different.
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