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Abstract #1942

Neurite orientation dispersion and density imaging (NODDI) to investigate tau pathology in a TG4510 mouse model of Alzheimers

Niall Colgan* 1 , Bernard Siow* 1,2 , James M O'Callaghan 1 , Jack A Wells 1 , Holly E Holmes 1 , Nick M Powell 1,2 , Ozama Ismail 1 , Simon Richardson 1,2 , Daniel C Alexander 2 , Emily C Collins 3 , Michael O'Neill 4 , Hui Zhang* 2 , and Mark F Lythgoe* 1

1 Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 2 Centre for Medical Image Computing, University College London, London, United Kingdom, 3 Eli Lilly and Company, Indianapolis, United States, 4 Eli Lilly & Co. Ltd, Surrey, United Kingdom

We applied neurite orientation dispersion and density imaging (NODDI) to estimate the microstructural changes due to tau pathology in the TG4510 (TG) animal model of Alzheimers disease (AD). The mouse model overexpresses a mutant human tau (P301L) resulting in intercellular tauopathies largely restricted to the hippocampus, cortex, olfactory bulb, and striatum. NODDI metrics discriminated between the wild type (WT) and TG is distinct regions of the brain associated with pathology.

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