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Abstract #1954

Diffusion Tensor Imaging Reveals White Matter Damage in the Optic Nerves of Alzheimers Patients

Christopher Nishioka 1 , Christina Poh 2 , and Shu-Wei Sun 2

1 University of California, Riverside, CA, United States, 2 Loma Linda University, CA, United States

Optic nerves of Alzheimers Disease (AD) patients were analyzed with diffusion tensor imaging (DTI) and compared to control patients. DTI scans were obtained from the Alzheimers Disease Neuroimaging Initiative (ADNI) database. Signs of white matter damage, including decreased fractional anisotropy, increased radial diffusivity and trace diffusion were seen in the AD patient population. These changes may be indicative of fiber loss and/or demyelination in the optic nerve.

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