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Abstract #1963

Disrupted modular organization and abnormal topological properties of the ACC in abstinent alcohol dependent patients to alcohol-cue reactivity

Guoying Wang 1 , Traute Demirakca 1 , Markus Sack 1 , Sabine Vollstaedt-Klein 2 , Derik Hermann 2 , Matthias Ruf 1 , Karl Mann 2 , and Gabriele Ende 1

1 Department of NeuroImaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany, 2 Department of Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

Brain activation in ACC to alcohol-related cues is able to elicit craving and relapse. In this ongoing study we used graph theory to test modular organization and topological properties of the ACC in abstinent alcohol dependent patients response to alcohol-associated cues. Repeated ANOVA analysis shows a trend towards decreased modularity in patients over early abstinence in which modular size as well as modular composition changed. This trend for less modularity implies an increasingly disrupted modular organization over early abstinence. Moreover, the ACC seems to be a hub in whole brain network with abnormal activity/importance in patients.

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