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Abstract #1979

The amygdalar driving effects for overeating in Prader-Willi syndrome

Ju Liu 1 , Jianliang Yao 1 , Siyou Qiu 1 , Yi Zhang 1 , and Yijun Liu 2

1 School of Life Science and Technology, Xidian University, Xi'an, Shanxi, China, 2 Department of Biomedical Engineering, Peking University, Beijing 100871, China

Prader-Willi syndrome(PWS) is a genetic imprinting disorder associated with hyperphagia and early childhood obesity.To study the neurobiological drive for overeating implicated in Prader-Willi syndrome,the current study combined the resting-state fMRI and Granger causality analysis (GCA) techniques to investigate the interactive causal influences among key neural pathways underlying overeating in PWS.Our data revealed significantly enhanced causal influences from theamygdala to the hypothalamus and from both the medial prefrontal cortex and anterior cingulate cortex to the amygdala. This study provides both a new methodological and neurobiological perspective to aid in a better understanding of neural mechanisms underlying common dietary obesity in the general public.

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