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Abstract #1983

MRS in early stage psychosis: Dependence on tissue fraction correction

Sin E. Robson 1 , Emma L. Hall 1 , Matthew J. Brookes 1 , Lena Palaniyappan 2 , Peter F. Liddle 2 , Mary C. Stephenson 1 , Molly Simmonite 2 , Elizabeth B. Liddle 2 , Michael Skelton 2 , Nikolaos G. Christodoulou 2 , Ayaz Qureshi 3 , and Peter G. Morris 1

1 School of Physics and Astronomy, University of Nottingham, Nottingham, Notts, United Kingdom, 2 Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, Notts, United Kingdom, 3 Nottinghamshire Healthcare NHS Trust, NHS, Nottingham, Notts, United Kingdom

Abnormalities in structure, function and neurotransmission are seen in patients with psychosis, particularly in nodes of the salience network: the anterior cingulate cortex (ACC) and insula. This study used 7T MRI and MRS to investigate tissue composition and metabolite concentrations in these regions and an occipital control region. Reductions in white matter were found in patients insula, along with decreases in glutamate concentration. Correction for tissue fraction removed the difference in glutamate, perhaps erroneously, since glutamate is mostly present in grey matter but differences in tissue fraction between patients and controls were seen in white matter only.

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