Improved Oxidative Metabolism and Cellular Redox State Following Sodium or Ethyl Pyruvate Supplementation after Experimental Traumatic Brain Injury
Brenda Bartnik-Olson 1 , Katsunori Shijo 2,3 , Sima Ghavim 2 , Neil Harris 2 , and Richard Sutton 2
Loma Linda University, Loma Linda, CA,
of California Los Angeles, Los Angeles, CA, United
University School of Medicine, Tokyo, Japan
Traumatic brain injury initiates a cascade of events
including increased oxidative stress that contributes to
the period of generalized metabolic depression.
Previously, sodium and ethyl pyruvate supplementation
was shown to reduce cell death, attenuate reductions in
cytochrome oxidase activity, and improve recovery
following experimental TBI. In this study we used 13C
NMR spectroscopy to determine if sodium or ethyl
pyruvate supplementation influences the activity of
metabolic pathways associated with the intracellular
redox state and oxidative metabolism. Our findings show
improvements in neuronal and astrocyte oxidative
metabolism following sodium pyruvate supplementation and
a reduction in the amount of glucose metabolized via the
pentose phosphate pathway following both sodium and
ethyl pyruvate use, suggesting an improved redox state.
These findings may explain, in part, the mechanisms
responsible for the beneficial effects of pyruvate
supplementation following experimental TBI.
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