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Abstract #2008

MR imaging of brain deformation during mild angular acceleration, referenced to brain anatomy and microstructure

Andrew Knutsen 1 , Philip Bayly 2 , Jerry Prince 3 , John Butman 4 , and Dzung Pham 1

1 Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation, Bethesda, MD, United States, 2 Washington University in St. Louis, MO, United States, 3 Johns Hopkins University, MD, United States, 4 Clinical Center, National Institutes of Health, MD, United States

Tagged MR images of brain deformation during mild angular acceleration were acquired in four live human subjects. High resolution MPRAGE and diffusion images were also acquired, and were registered into the tagged image space. Two-dimensional principal strains were computed from the tagged MR images and mapped into anatomical structures identified using the MPRAGE. Strains were also computed along principal fiber directions identified via DTI. Quantifying strain in the live human brain is important to understand the role that brain structure plays in the deformation response to skull acceleration, and to help validate computation models of traumatic brain injury.

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