MR imaging of brain deformation during mild angular acceleration, referenced to brain anatomy and microstructure
Andrew Knutsen 1 , Philip Bayly 2 , Jerry Prince 3 , John Butman 4 , and Dzung Pham 1
Center for Neuroscience and Regenerative
Medicine, The Henry M. Jackson Foundation, Bethesda, MD,
University in St. Louis, MO, United States,
Hopkins University, MD, United States,
Center, National Institutes of Health, MD, United States
Tagged MR images of brain deformation during mild
angular acceleration were acquired in four live human
subjects. High resolution MPRAGE and diffusion images
were also acquired, and were registered into the tagged
image space. Two-dimensional principal strains were
computed from the tagged MR images and mapped into
anatomical structures identified using the MPRAGE.
Strains were also computed along principal fiber
directions identified via DTI. Quantifying strain in the
live human brain is important to understand the role
that brain structure plays in the deformation response
to skull acceleration, and to help validate computation
models of traumatic brain injury.
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