Abstract #2010
Diffusion Tensor Imaging of Blast Induced Traumatic Brain Injury in Rodent Model
Sanjay K Verma 1 , Bhanu Prakash KN 1 , Sankar Seramani 1 , Enci Mary Kan 2 , Kian Chye Ng 2 , Mui Hong Tan 2 , Jia Lu 2 , and S Sendhil Velan 1,3
1
Laboratory of Molecular Imaging, Singapore
Bioimaging Consortium, Singapore, Singapore,
2
Combat
Protection and Performance Lab, DSO National
Laboratories, Singapore, Singapore,
3
Clinical
Imaging Research Centre, Agency for Science, Technology
and Research, Singapore, Singapore, Singapore, Singapore
Traumatic brain injury due to blasts by improvised
explosive devices is increasing, creating various
neuropsychological dysfunctions such as attention
deficit, working function, motor skills etc in both
animals and humans. We investigated the effect of open
field blast injuries on rat brain using Diffusion tensor
imaging which provides the degree as well as
directionality of water diffusion in brain. The increase
in FA , AD and decrease in RD at day 1 in CC may be
probably due to edema or change in the water content
within the myelin sheath. Decrease of diffusivity in the
cortex and hippocampus indicates cytotoxic edema and
slight increase at day 28 probably due to reduced tissue
cellularity.
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