Cerebrovascular reactivity as objective markers of hemodynamic compromise: A pilot study
Olivia Sobczyk 1,2 , Daniel M. Mandell 2 , Kevin Sam 2,3 , Adrian Crawley 2 , Julien Poublanc 2 , David Mikulis 2 , James Duffin 3,4 , and Joseph Fisher 3,4
Institute of Medical Science, University of
Toronto, Toronto, Ontario, Canada,
of Medical Imaging, University Health Network, Toronto,
Department of Physiology,
University of Toronto, Toronto, Ontario, Canada,
University Health Network, Toronto, Ontario, Canada
We used cerebrovascular reactivity (CVR), the change in
cerebral blood flow, as measured using BOLD MRI in
response to a hypercapnic vasodilatory stimulus to test
neurovascular reserve. We scored CVR values
voxel-by-voxel in terms of statistical differences from
the corresponding voxel in a cohort of healthy subjects.
We averaged the z-scores in the MCA territories in a
cohort of patients with steno-occlusive disease and in
healthy subjects. Frequency distribution histograms
showed only a small overlap in average z-values between
patients and healthy subjects suggesting this analysis
may be a sensitive and specific objective discriminator
for steno-occlusive disease.
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