Abstract #2052
Comparison of efficacy of diffusion kurtosis imaging in detection of occult brain damages in neuromyelitis optica and multiple sclerosis
Wenshu Qian 1 , Koon-Ho Chan 2 , Mina Kim 1 , and Henry Ka-Fung Mak 1
1
Diagnostic Radiology, The University of Hong
Kong, Hong Kong, China,
2
Medicine,
The University of Hong Kong, Hong Kong, China
Early diagnosis and differentiation of neuromyelitis
optica (NMO) from multiple sclerosis (MS) is vital to
provide timely and proper treatment. However,
conventional MRI techniques are not sensitive to assess
the occult microstructural changes in brain tissues in
the early or stable stage. In this study, we
investigated the normal-appearing white matter and
cortical gray matter in controls and patients with NMO
and MS using diffusion kurtosis imaging (DKI). Our
results demonstrate that DKI-derived indices are
sensitive to detect the microstructural abnormalities
and can distinguish pathological alterations in NMO from
MS, suggesting DKI may be a useful diagnostic tool of
NMO.
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