Abstract #2075
Intralesional vein shrinking in multiple sclerosis lacks in severeness -preliminary results from a 7T MRI study
Katharina Mller 1 , Joseph Kuchling 1 , Ivan Bozin 1 , Jan Drr 1 , Caspar Pfueller 1 , Lutz Harms 2 , Thoralf Niendorf 3 , Friedemann Paul 1 , Tim Sinnecker 1,4 , and Jens Wuerfel 1,5
1
Neurocure Research Center, Berlin, Berlin,
Germany,
2
Department
of Neurology, Charit Universittsmedizin Berlin,
Berlin, Berlin, Germany,
3
Berlin
Ultrahigh Field Facility (B.U.F.F), Max Delbrueck Center
for Molecular Medicine, Berlin, Berlin, Germany,
4
Asklepios
Fachklinikum Teupitz, Brandenburg, Germany,
5
Institute
of Neuroradiology, University Medicine Goettingen,
Goettingen, Germany
Vascular alterations in multiple sclerosis (MS) have
been described decades ago. T2* weighted ultrahigh field
MRI at 3 Tesla (T) visualized shrinked brain veins
within MS plaques in vivo. However, this observation may
be influenced by partial volume effects. We addressed
this issue by developing a novel quantification
algorithm and a novel MR-post processing procedure that
generates susceptibility weighted turbo inversion
recovery magnitude (sTIRM) images. We observed less
intralesional venous shrinking on sTIRM compared to T2*
weighted FLASH imaging. Our results confirm initial
reports showing venous shrinking within MS lesions that
is probably not as severe as expected.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
