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Abstract #2077

Permeability of the blood-brain barrier predicts conversion from Optic Neuritis to Clinically Definite Multiple Sclerosis

Stig Praestekjaer Cramer 1,2 , Helle Simonsen 1 , Signe Modvig 2 , Jette Lautrup Frederiksen 2 , and Henrik BW Larsson 1

1 FI-Unit, Department of Diagnostics, University of Copenhagen, Glostrup, Danmark, Denmark, 2 Department of Neurology, University of Copenhagen, Glostrup, Danmark, Denmark

We measured permeability of the blood-brain-barrier with DCE_MRI in 32 patients at onset of Optic Neuritis and 17 matched healthy controls. We found significnatly higher permeability in normal appearing white matter ON patients compared to controls, and permeability was significantly correlated with biomarkers of inflammation and cell migration in the cerebrospinal fluid. In 50% of ON cases, the patient will later develop multiple sclerosis, and we found significant higher permeability in patients that where diagnosed with MS within one year after ON onset. These findings further emphasize the importance of BBB pathology in both ON and MS, and could be a supplementary prognostic marker for conversion from ON to MS.

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