Abstract #2080
Altered cerebrovascular reactivity and its restoration with Interferon beta treatment in multiple sclerosis
Marek Allen 1 , Valentina Tomassini 2 , Nikolaos Petsas 3 , Marco Carni 3 , Emilia Sbardella 3 , Kevin Murphy 1 , Patrizia Pantano 3 , Carlo Pozzilli 3 , and Richard Wise 1
1
CUBRIC, School of Psychology, Cardiff
University, Cardiff, Cardiff, United Kingdom,
2
School
of Medicine, Institute of Psychological Medicine and
Clinical Neurosciences, Cardiff, Cardiff, United
Kingdom,
3
Department
of Neurology and Psychiatry, Sapienza University of
Rome, Rome, Italy
Cerebrovascular reactivity (CVR) is the capacity of
blood vessels to increase blood flow to brain tissue, a
process essential for preserved neurovascular coupling.
Using breath hold-induced hypercapnia we aimed to
investigate CVR in multiple sclerosis patients and the
effect of interferon-beta treatment. We discovered a
reduced reactivity in patients compared with healthy
controls independent of distributed grey matter density
reductions. This was reversed following commencement of
interferon-beta1a treatment to a level comparable with
controls. The effect of immunomodulation on CVR in
patients suggests altered CVR is related to MS
inflammatory activity and could indicate a marker for
early therapeutic effect.
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