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Abstract #2096

Nigrostriatal pathway evaluation with diffusion MRI and three-dimensional histological analysis in a monkey model of Parkinson s disease

Keigo Hikishima 1,2 , Kiyoshi Ando 1 , Ryutaro Yano 3 , Yuji Komaki 1,2 , Kenji Kawai 1 , Takashi Inoue 1 , Masayuki Yamada 4 , Toshio Itoh 1 , Suketaka Momoshima 5 , Hirotaka James Okano 6 , and Hideyuki Okano 2

1 Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan, 2 Department of Physiology, Keio University School of Medicine, Shinjuku, Tokyo, Japan, 3 Faculty of Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, 4 School of Health Science, Fujita Health University, Aichi, Japan, 5 Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan, 6 Division of Regenerative Medicine, Jikei University School of Medicine, Tokyo, Japan

Movement dysfunction in Parkinsonfs disease is caused by the degeneration of dopaminergic neurons in the substantia nigra pars compacta. We used a microscopic diffusion tensor tractography (DTT) technique with an isotropic resolution of 60 m and three-dimensional histological analysis to visualize the nigrostriatal pathway in the common marmoset, a small non-human primate. We also developed longitudinal voxel-based analysis to detect the distribution of degeneration. In this study, we report that microscopic DTT visualized the nigrostriatal pathway and longitudinal voxel-based analysis assessed neuronal degeneration in a monkey model of Parkinsonfs disease.

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