Metabolic Alterations in Rat Brain due to Chronic High Altitude Stress: A 1H-MRS study
Sunil Koundal 1 , Sonia Gandhi 1 , Tanzeer Kaur 2 , Rajendra P Tripathi 1 , and Subash Khushu 1
NMR Research Centre, Institute of Nuclear
Medicine and Allied Sciences (INMAS), Timarpur, Delhi,
of Biophysics, Panjab University, Chandigarh, India
Neurometabolic alterations in response to chronic high
altitude stress were studied with 1H-MR Spectroscopy.
Inositol and choline concentrations were significantly
decreased after 7 and 14 days of altitude exposure which
was linked to altered astrocyte metabolism and neuronal
rescue effort respectively. A significant decrease in
Glutamate+Glutamine after 14 day hypoxia reflected
altered glutamate metabolism. An increment in taurine
reflects protective effect from excitotoxic injury.
There was no significant NAA change, implying retained
neuronal integrity. This study along with in vitro High
resolution NMR spectroscopy and other biochemical
analysis may provide better insights of the injury and
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