A pathophysiological wiring defect in epileptic animals as depicted by DTI fiber tracking
Ulysse Gimenez 1 , Fanny Cavarec 2 , Antoine Depaulis 2 , Hana Lahrech 1 , and Colin Deransart 2
CEA-Clinatec, Grenoble, France,
Institute of Neurosciences, La Tronche, France
The Genetic Absence Epilepsy Rats from Strasbourg
(GAERS) is a well-validated model of absence epilepsy,
and dopamine has been shown to play a modulatory role on
absence seizures. The fasciculus retroflexus (FR) is a
white matter tract involved in the release of dopamine.
A microscopic 3D-Diffusion Tensor Imaging sequence was
developed on 7T Bruker MRI and applied ex vivo on GAERS
and Non Epileptic Control (NEC) rats. DTI fiber-tracking
showed a decrease in the number of fibers detected in
the FR, suggesting a contribution of this tract in the
modified dopaminergic tone observed in epileptic rats.
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