Abstract #2109
In vivo MEMRI brain atlas for NOD/scid- c null mouse model of neuroAIDS
Balasrinivasa R Sajja 1 , Aditya N Bade 2 , Biyun Zhou 3 , Mariano G Uberti 1 , Santhi Gorantla 2 , Larisa Y Poluektova 2 , Michael D Boska 1,2 , Howard E Gendelman 2 , and Yutong Liu 1,2
1
Radiology, University of Nebraska Medical
Center, Omaha, Nebraska, United States,
2
Pharmacology
and Experimental Neuroscience, University of Nebraska
Medical Center, Omaha, Nebraska, United States,
3
Anesthesiology,
Tongji Medical College, Huanzhong University of Science
and Technology, Wuhan, China
Longitudinal morphological phenotyping of HIV-1 mouse
model can provide an assessment of brain structural
changes during disease progression and therapeutic
responses. An in vivo MEMRI based NSG mouse brain atlas
was generated to assess volumetric effects on brain
structures from the process of generating humanized
mice. Our results determined significant size reduction
in humanized mice brain structures. This procedure will
be extended to track structure-wise changes during
progression of HIV-1 infection in NSG human cell
transplanted mice.
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