Quantitative assessment of global small bowel motility in Chronic Intestinal Pseudo-Obstruction and controls: A Preliminary Study
Alex Menys 1 , Shamaila Butt 2 , Anton Emmanuel 2 , Natalia Zarate 2 , David Atkinson 3 , Andrew Plumb 3 , and Stuart A Taylor 3
Centre for Medical Imaging, UCL, London,
Select, United Kingdom,
Physiology Unit, UCLH, London, United Kingdom,
for Medical Imaging, UCL, London, United Kingdom
Quantified small bowel (SB) motility, assessed by
analysis of dynamic MRI images, is an emerging tool for
the investigation of dysmotility in a range of diseases.
In this study, we report the initial findings with
respect to global SB motility in a group of Chronic
Intestinal pseudo-obstruction patients against healthy
controls. We found a significant difference in basal
small bowel motility between groups and, upon challenge
with a pro-kinetic drug, increases in bowel motility in
both groups. This study demonstrates the first clinical
application of global SB motility analysis and
encouraging results for the quantitative investigation
of dysmotility in disease.
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