Abstract #2123
Diffusion MRI in Crohn's Disease: Comparison with Fecal Calprotectin and MR-Enterography
Douglas Andrew Pendse 1 , Jesica Makanyanga 1 , Andrew Plumb 1 , David Atkinson 1 , and Stuart Taylor 1
1
Centre for Medical Imaging, University
College London, London, London, United Kingdom
Therapeutic strategies in Crohns disease are dependent
on both the degree of disease activity and the overall
burden of disease in the gut. In this study we evaluated
diffusion MRI (DWI) of the bowel in 69 adult patients
with Crohns disease, using validated methods of MEGS
score on MR-Enterography (MRE) and fecal Calprotectin (fC)
as reference standards. Patients with abnormal DWI were
shown to have significantly higher levels of fC and had
higher MEGS score on conventional MRE. These data
suggest that diffusion MRI is a clinically useful tool
in the evaluation of Crohns activity.
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