Abstract #2128
Free-breathing quantification of liver proton density fat-fraction
Utaroh Motosugi 1,2 , Diego Hernando 1 , Peter Bannas 1,3 , James H. Holmes 4 , Kang Wang 4 , Ann Shimakawa 5 , Yuji Iwadate 6 , Valentina Taviani 7 , and Scott B. Reeder 1,8
1
Radiology, University of Wisconsin, Madison,
WI, United States,
2
Radiology,
University of Yamanashi, Chuo-shi, Yamanashi, Japan,
3
Radiology,
University Hospital Hamburg-Eppendorf, Hamburg, Germany,
4
Global
MR Applications and Workflow, GE Healthcare, Madison,
WI, United States,
5
Global
MR Applications and Workflow, GE Healthcare, Menlo Park,
CA, United States,
6
Global
MR Applications and Workflow, GE Healthcare, Hino,
Tokyo, Japan,
7
Radiology,
Stanford University, Stanford, CA, United States,
8
Medical
Physics, Biomedical Engineering and Medicine, University
of Wisconsin, Madison, WI, United States
Proton density fat fraction (PDFF) is a promising
biomarker for early detection and treatment monitoring
of fatty liver disease. In order to obtain whole-liver
coverage, current chemical shift-encoded MRI requires
breath-holding for ~20s. In this study, we established
two new free-breathing chemical shift-encoded MRI
methods to acquire PDFF maps, and compared these methods
to breath-hold MRI and MR spectroscopy. We found that
the free-breathing methods (respiratory-gating with
bellows or navigator echoes) were both equivalent to the
breath-hold sequence for liver fat quantification. These
novel sequences may be helpful for pediatric patients or
patients who are unable to perform breath-holding.
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