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Abstract #2136

Quantitative comparison of hepatic fat fraction in type 2 diabetes with triple-echo gradient echo MRI and proton MRS

Sunil K. Valaparla 1,2 , Goldie R. E. Boone 1 , Feng Gao 1 , Timothy Q. Duong 1,2 , and Geoffrey D. Clarke 1,2

1 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States, 2 Radiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States

Type 2 diabetes (T2DM) has been associated with excessive fat accumulation in the liver and definitive diagnosis using non-invasive fat estimation methods is essential for early treatment. We measured the liver fat fraction in T2DM subjects using triple-echo GRE MRI and compared with current gold standard 1H-MRS. BlandAltman plots and regression analysis between methods exhibited excellent concordance and correlation. Triple-echo GRE MRI is fast, accurate, provides excellent concordance and correlation with MRS and can be used to replace time-consuming MRS for longitudinal and large cohort studies.

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