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Abstract #2144

Visual identification of brown adipose tissue in adult humans using Dixon MRI

Terence Jones 1 , Narendra Reddy 2 , Sarah Wayte 3 , Oludolapo Adesanya 4 , Thomas Barber 5 , and Charles Hutchinson 1

1 Medical School, University of Warwick, Coventry, West Midlands, United Kingdom, 2 Metabolic Health, University Hospitals Coventry & Warwickshire, Coventry, CV2 2DX, United Kingdom, 3 Medical Physics, University Hospitals Coventry & Warwickshire, Coventry, CV2 2DX, United Kingdom, 4 Radiology, University Hospitals Coventry & Warwickshire, Coventry, West Midlands, United Kingdom, 5 Health Sciences, University of Warwick, Coventry, West Midlands, United Kingdom

Ongoing interest in brown adipose tissue (BAT) has led to research in MRI as a potential tool for identifying and quantifying BAT, which is a necessary precursor to clinical trials evaluating pharmacological agents to stimulate BAT. We conducted a study in which areas of potential BAT were identified visually on Dixon MRI and compared with metabolically BAT on PET-CT using colocalization. Visual identification of BAT underestimates BAT volume, particularly when large levels of BAT are present. Conversely the degree of colocalization increases with increasing BAT volumes. This technique may be useful is evaluating future methods of prospective BAT identification.

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