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Abstract #2150

MR Tagging based cardiac-induced liver deformation analysis in murine model of non-alcoholic fatty liver disease

Anna Osiak 1 , Krzysztof Jasinski 1 , Pawel T. Jochym 2 , Edyta Maslak 3 , and Tomasz Skorka 1

1 Department of Magnetic Resonance Imaging, Institute of Nuclear Physics Polish Academy of Sciences, Krakw, Poland, 2 Department of Materials Research by Computers, Institute of Nuclear Physics Polish Academy of Sciences, Krakw, Poland, 3 Department of Endothelium Experimental Pharmacology, Jagiellonian Center for Experimental Therapeutics (JCET), Krakw, Poland

The objective was to assess cardiac-induced liver deformation in murine model of non-alcoholic fatty liver disease (NAFLD) using MR Tagging. Control and NAFLD mice were examined and liver tissue displacements Disp, E1 and E2 principal strains were computed within 7 regions and normalized to maximum heart declination. In NAFLD the tissue compression increased, maximum Disp and E1 were preserved, but the deformation were propagated deeper in the organ compared to controls, what may reflect increased fat deposition at non-fibrotic stage of pathology. Good consistency of the results suggests the routine may be helpful for evaluation of fat deposition degree.

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