Ultra Low Dose Free breathing Quantitative Renal Perfusion and Filtration using 3D Through-time Radial GRAPPA
Katherine L. Wright 1 , Yong Chen 2 , Mark A. Griswold 1,2 , Nicole Seiberlich 1 , and Vikas Gulani 1,2
Biomedical Engineering, Case Western Reserve
University, Cleveland, Ohio, United States,
Case Western Reserve University, Cleveland, Ohio, United
This work demonstrates 3D quantitative renal DCE MRI
using half and quarter doses (by weight) of a gadolinium
based contrast agent and no breath-holds. Data are
acquired with a highly accelerated stack-of-stars
acquisition, reconstructed using 3D through-time radial
GRAPPA, and registered to remove respiratory motion.
This exam provides 3D quantification of perfusion,
filtration, and mean transit times at clinically
relevant spatial resolutions using very low doses of
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