Abstract #2210
New Magnetic Nanoparticle for Kidney Function
Yoshichika Yoshioka 1,2 , Ting Chen 1 , Yuki Mori 1,2 , Zhenyu Cheng 1 , Yuuto Kashiwagi 1 , Masaki Fukunaga 2,3 , Ikuhiro Kida 1,2 , Yoshiyuki Tago 4 , Shinichi Yoshida 4 , and Kohji Ohno 5
1
Immunology Frontier Research Center (IFReC),
Osaka University, Suita, Osaka, Japan,
2
Center
for Information and Neural Networks (CiNet), National
Institute of Information and Communications Technology (NICT)
and Osaka University, Suita, Osaka, Japan,
3
1Immunology
Frontier Research Center (IFReC), Osaka University,
Suita, Osaka, Japan,
4
Frontier
Biochemical and Medical Research Laboratories, Kaneka
Corporation, Takasago, Hyogo, Japan,
5
Institute
for Chemical Research, Kyoto University, Uji, Kyoto,
Japan
The biodistribution pattern of newly synthesized
magnetic nano particles was investigated in mice. The
particles are taken little by Kupffer cells and
peripheral macrophages and have the long half-life in
mouse blood circulation. The particles showed the marked
distribution pattern especially in the mouse kidney. The
particles retained much in the renal cortex and in the
boundaries between cortex and medulla and between outer
medulla and inner medulla. The dark round spots in the
renal cortex were confirmed as renal corpuscles. These
distribution patterns could be used as a measure of
renal functions.
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