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Abstract #2232

Serum Metabolic Signature in an animal model of binge eating by Nuclear Magnetic Resonance Spectroscopy

Valeria Righi 1 , Silvia Alboni 2 , Luisa Schenetti 2 , Carlo Cifani 3 , Nicoletta Brunello 2 , and Adele Mucci 4

1 Department for the Quality of Life Studies, University of Bologna, Rimini, RN, Italy, 2 Department of Life Sciences, University of Modena and Reggio Emilia, Modena, MO, Italy, 3 School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, MC, Italy, 4 Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Modena, MO, Italy

Binge Eating (BE) episodes are characterized by uncontrollable, distressing eating of a large amount of highly palatable food (HPF). Considerable evidence suggests that BE may be caused by a unique interaction between dieting and stress. In our model BE for HPF is evoked in rats by the combination of cyclic food restrictions and stress. In order to investigate BE behavior in female rats, for the first time, we analyzed the metabolic profile obtained from biological fluids of rats exposed or not to cycles of food restriction and a stressful challenge through the High Resolution Nuclear Magnetic Resonance Spectroscopy.

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