Study of chronological effects of iodinated contrast medium on intrarenal water molecular diffusion by diffusion-weighted MR imaging
Jia Liu 1 , Kai Zhao 1 , and Xiaoying Wang 1
Peking University First Hospital, Beijing,
Usage of iodinated contrast medium during radiological
procedure may cause contrast induced nephropathy (CIN).
Unfortunately the pathogenesis of CIN is currently
unclear, and maybe characteristics of contrast medium
affect the development of CIN. Our study demonstrated
that it is feasible to monitor the time course effects
on renal function after different iodinated contrast
medium administration in rabbit models using
diffusion-weighted MR imaging. Iopamidol-370 causes more
deterioration on intrarenal water transport function
than iodixanol-320. This may be helpful to understand
the pathogenesis associated with CIN. We introduce a
clinical clue to choose better contrast medium to
prevent the incidence of CIN.
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