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Abstract #2259

Interethnic differences in fatty acid composition of deep subcutaneous abdominal adipose tissue

Suresh Anand Sadananthan 1,2 , Navin Michael 1 , Melvin K-S Leow 1,3 , ChinMeng Khoo 4 , Eric Yin Hao Khoo 4 , Yung Seng Lee 1,5 , Peter Gluckman 1 , EShyong Tai 4 , and S. Sendhil Velan 1,6

1 Singapore Institute for Clinical Sciences, A*STAR, Singapore, Singapore, 2 Department of Obstetrics & Gynaecology, National University of Singapore, Singapore, Singapore, 3 Department of Endocrinology, Tan Tock Seng Hospital, Singapore, 4 Department of Medicine, National University of Singapore, Singapore, 5 Department of Pediatrics, National University of Singapore, Singapore, 6 Clinical Imaging Research Centre, A*STAR, Singapore

The study of fat distribution is important to understand the pathophysiology of obesity-related disorders, diabetes mellitus and cardiovascular diseases. Several studies have suggested that the fat distribution is different across different ethnic groups. In addition to the analysis of fat distribution, the investigation of the fatty acid composition is also important because of their varying metabolic properties and association with insulin sensitivity. Differences in the fatty acid composition induced by diet or ethnicity could potentially make some groups more susceptible to metabolic disorders. In this study, we investigated the fatty acid composition in the abdominal deep subcutaneous adipose tissue of three ethnicities (Chinese, Malays and Indians) non-invasively using MRS approaches.

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