Abstract #2261
Diastolic Dysfunction Is Temporally Dissociated from Myocardial Steatosis
Michael D Nelson 1 , Laura Smith 1 , Edward W Szczepaniak 1 , Ruchi Mathur 1 , Richard N Bergman 1 , and Lidia S Szczepaniak 1
1
Cedars-Sinai Medical Center, Los Angeles,
California, United States
The risk for heart failure in obesity and diabetes is
greater than can be accounted for by traditional factors
of hypertension and coronary artery disease. Altered
substrate metabolism may contribute to dysfunction of
diabetic heart. In obesity and diabetes contribution of
glucose oxidation to cardiac energetics is sub-normal
with enhanced reliance on fatty acid metabolism. Most
work in cardiac metabolism has been performed in rodent
models. We present results from a study in which we
altered cardiac metabolism by 48 hours fasting in
humans. Cardiac metabolism was assessed by myocardial
triglyceride content and diastolic function assessed by
myocardial tissue tagging.
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