Comparison of T1, T2 and PDFF measured by 1 H MR spectroscopy with histologic fibrosis stage.
Gavin Hamilton 1 , Michael S Middleton 1 , Tanya Wolfson 2 , Anthony C Gamst 2 , Jonathan C Hooker 1 , William M Haufe 1 , Brandon D Ang 3 , Rohit Loomba 3 , and Claude B Sirlin 1
Department of Radiology, UC San Diego, San
Diego, California, United States,
and Applied Statistics Laboratory, SDSC, UC San Diego,
San Diego, California, United States,
of Medicine, UC San Diego, San Diego, California, United
We developed a rapid multi-TR, multi-TE
MRS sequence for
fat quantification and characterization that acquires 32
single-average spectra in a single breath-hold. Spectra
were acquired without contrast at 3 Tesla in 55 adult
subjects who also were undergoing a clinical liver
biopsy. T1 and T2 of liver fat and water, and liver
proton density fat fraction (PDFF) were measured and
compared with histologic fibrosis stage. There were
significant differences in water T2 with fibrosis, with
higher values being associated with advanced fibrosis.
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