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Abstract #2273

Hyperpolarized pyruvate allows early detection of lactate in real-time metabolism of acute liver failure rats

Laia Chavarria 1,2 , Jordi Romero-Gimnez 1,2 , Eva Monteagudo 3 , Juan Crdoba 1,2 , and Silvia Lope-Piedrafita 3,4

1 Liver Unit, Hospital Vall Hebron, Barcelona, Barcelona, Spain, 2 Centro de Investigacin Biomdica en Red de Enfermedades Hepticas y Digestivas (CIBEREHD), Barcelona, Barcelona, Spain, 3 Servei de RMN, Universitat Autnoma de Barcelona, Cerdanyola del Valls, Barcelona, Spain, 4 Centro de Investigacin Biomdica en Red en Bioingeniera, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain

Intracranial hypertension is a severe complication of acute liver failure (ALF) secondary to brain edema. The pathogenesis of cerebral edema in ALF is not clear but it is known that energy metabolism alterations are involved where a genesis of lactate seems to have an important role. We have studied the dynamic synthesis of brain metabolites using hyperpolarized 1-13C pyruvate in a rat model of ALF. We have found that ALF rats have a significant increase in the lactate/pyruvate ratio as compared to Control rats. Also, the production rate of lactate and alanine was higher in ALF rats.

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