Comparison of global multiple breath washout measured at the mouth to imaging multiple breath washout in healthy subjects and CF patients.
Felix Horn 1 , Juan Parra-Robles 1 , Helen Marshall 1 , Christopher Taylor 2 , Alex Horsley 3 , and Jim Wild 1
Academic Radiology, University of Sheffield,
Sheffield, South Yorkshire, United Kingdom,
Children's Hospital, Sheffield, South Yorkshire, United
CF Centre, University of Manchester, Manchester, United
Previously it was shown how gas washout measured with
hyperpolarized helium-3 MRI can be used to obtain
quantitative regional lung function in 3D (MBW-I).
Multiple breath inert gas washout as clinically
performed in the pulmonary function lab (MBW) is a
technique thought to be sensitive to early signs of
ventilation heterogeneity in obstructive lung diseases
like CF. In this preliminary work MBW-I and MBW were
performed in healthy controls and CF patients. MBW-I was
found to be comparable to conventional MBW, an important
pre-requisite for the subsequent regional interpretation
of ventilation heterogeneity.
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