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Abstract #2294

In vivo observations of radiation damping effects from tissue-dissolved hyperpolarized 129Xe

Rosa Tamara Branca 1,2 , Le Zhang 3 , and Carlos Floyd 4

1 Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2 Biomedical Research Imaging Center, Chapel Hill, NC, United States, 3 Material Science, University of North Carolina at Chapel Hill, NC, United States, 4 Physics and Astronomy, University of North Carolina at Chapel Hill, NC, United States

The low gyromagnetic ratio of xenon, the relatively low polarizability and concentration achievable in distal organs upon HP-129Xe gas inhalation suggest that in in vivo settings the observation of radiation damping is highly unlikely. Nonetheless we report the first observation of radiation damping effects from tissue-dissolved hyperpolarized xenon and a revision of the xenon uptake model to account for the strong local xenon uptake that leads to the observation of these effects.

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