Reconciling the Discrepancy Between Theory and Observed Hyperpolarized 129 Xe Polarizer Performance
Matthew S Freeman 1,2 , Kiarash Emami 3 , and Bastiaan Driehuys 1,2
Medical Physics Graduate Program, Duke
University, Durham, NC, United States,
for In Vivo Microscopy, Duke University, Durham, NC,
Inc., Durham, NC, United States
While hyperpolarized (HP)
MRI shows great promise as a functional imaging
modality, it remains limited by HP
polarization and production rates. Despite notable
recent successes, most polarizers greatly underperform
compared to theoretical predictions of the standard
model of spin-exchange optical pumping (SEOP). Here we
characterize 6 combinations of optical cells and lasers,
and show that by postulating the generation of recently
discovered paramagnetic Rb fractal clusters within the
SEOP environment, observed performance can be explained.
Rb fractal clusters, if confirmed, would strongly impact
future polarizer designs, and if mitigated, would
restore full theoretically predicted performance.
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