Pharmacodynamic analysis of gadodiamides diffusion through the focused-ultrasound blood-brain barrier opening in non-human primates in vivo using Magnetic Resonance Imaging
, Sachin Jambawalikar
and Elisa E Konofagou
Biomedical Engineering, Columbia University,
New York, NY, United States,
of Radiology, Columbia University, NY, United States
In this study, pharmacodynamic analysis of gadodiamides
diffusion through the focused-ultrasound blood-brain
barrier opening in non-human primates in vivo was
performed. Physiologic properties, such as the volume of
opening and the concentration of gadodiamide in the
opened area, were studied and quantified using T1
relaxivity and ΔR1 mapping.
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