Abstract #2337
Pharmacodynamic analysis of gadodiamides diffusion through the focused-ultrasound blood-brain barrier opening in non-human primates in vivo using Magnetic Resonance Imaging
Gesthimani Samiotaki
1
, Sachin Jambawalikar
2
,
and Elisa E Konofagou
1,2
1
Biomedical Engineering, Columbia University,
New York, NY, United States,
2
Department
of Radiology, Columbia University, NY, United States
In this study, pharmacodynamic analysis of gadodiamides
diffusion through the focused-ultrasound blood-brain
barrier opening in non-human primates in vivo was
performed. Physiologic properties, such as the volume of
opening and the concentration of gadodiamide in the
opened area, were studied and quantified using T1
relaxivity and ΔR1 mapping.
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