Magnetic resonance imaging assessment of excess cardiac iron in thalassemia major: when to initiate?
Xiaodong Chen 1,2 , Zuoquan Zhang 3 , Jinglian Zhong 4 , Qihua Yang 4 , Ziliang Cheng 4 , and Biling Liang 4
Sun Yat-Sen Memorial Hospital, Guang Zhou,
Guang Dong, China,
Medical College, Guangdong, China,
Fifth Affiliated Hospital of Sun Yat-Sen University,
Yat-Sen Memorial Hospital, Guangdong, China
To study the optimal initial age of cardiac iron
screening with MRI T2* in patients with thalassemia
major(TM). We retrospectively reviewed of cardiac T2*
assessments from 102 TM patients between the ages of 3
to 32 years. We found that no patient under 5 years old
showed detectable cardiac iron. Cardiac iron level
correlated weakly with ferritin and liver iron, but not
with patient age. So we drew a conclusion that cardiac
iron overload can occur in young patients and assessment
of cardiac iron with MRI should be initiated as early as
5 years of age, even in asymptomatic patients.
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