Abstract #2426
Multi-parametric MRI assessment of myocardial ischemia-reperfusion injury in mice
Adrienne E Campbell-Washburn 1 , Rachel K Dongworth 2 , Thomas A Roberts 3,4 , Anthony N Price 5 , David L Thomas 6 , Roger J Ordidge 7 , Derek M Yellon 2 , Derek J Hausenloy 2 , and Mark F Lythgoe 3
1
Division of Intramural Research, National
Heart, Lung and Blood Institute, National Institutes of
Health, Bethesda, Maryland, United States,
2
The
Hatter Cardiovascular Institute, University College
London, London, United Kingdom,
3
Centre
for Advanced Biomedical Imaging, University College
London, London, United Kingdom,
4
Centre
for Mathematics and Physics in the Life Sciences &
Experimental Biology, University College London, London,
United Kingdom,
5
Division
of Imaging Sciences and Biomedical Engineering, St
Thomas' Hospital, King's College London, London, United
Kingdom,
6
Department
of Brain Repair and Rehabilitation, Institute of
Neurology, University College London, London, United
Kingdom,
7
Centre
for Neuroscience, University of Melbourne, Melbourne,
Australia
In order to assess myocardial salvage when evaluating
new therapeutic strategies for myocardial infarction, we
require the measurement of both infarct size and
area-at-risk. In this study, a multi-parametric analysis
of infarct (late gadolinium enhancement), oedema (T2
mapping) and perfusion (arterial spin labeling, ASL) is
presented for ischemia-reperfusion injury in a mouse
model. Late enhancement and T2 mapping correspond well
to infarct size and area-at-risk (respectively), as
expected. Interestingly, multi-slice ASL shows perfusion
deficits, which correspond to area-at-risk, despite
reperfusion. This platform will be a useful tool for in
vivo investigation of AAR pathophysiology following
ischemia-reperfusion injury.
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