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Abstract #2434

Cardiac diffusion MRI beyond DTI

Valentina Mazzoli 1 , Martijn Froeling 1,2 , Aart J Nederveen 3 , Klaas Nicolay 1 , and Gustav J Strijkers 1

1 Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 2 Department of Radiology, University Medical Center, Utrecht, Netherlands, 3 Department of Radiology, Academic Medical Center, Amsterdam, Netherlands

Conventional Diffusion Tensor Imaging (DTI) has been extensively applied to study myocardial fiber architecture. However, due to the inability in identifying crossing fibers and low sensitivity on microstructural characteristics, DTI fails to provide a detailed picture of the (micro)structure of cardiac muscle. We therefore proposed the use of DKI and CSD to the study of the ex-vivo porcine heart. DKI showed a better sensitivity than normal DTI to regional microstructural differences across the wall, and CSD was correctly able to identify crossing myoloaminar structures. These techniques could be useful for reaching a deeper knowledge of cardiac structure and function.

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