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Abstract #2461

Dynamic changes of myocardial salvage index after reperfusion: A rat study at 7T

Rui Xia 1 , Xi Lu 1 , Bing Zhang 1 , Yuqing Wang 1 , Jie Zheng 2 , and Fabao Gao 1

1 Department of radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China, 2 Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, Missouri, United States

In this study, six rats with 30min myocardial ischemia followed by different reperfusion time (3h, 6h, 12h, 24h) were investigated. And the simplified T2-mapping method was implemented at a 7.0T MRI system. We found that the edema size decreased from 3h to 6h, and kept the same between 6h and 24h. Myocardial salvage index increased while infarction size decreased from 6h to 24h. So the longer reperfused time will increase myocardial salvage index between 6h and 24h in the acute myocardial ischemia. In conclusion, reperfusion may be a useful treatment for the early phase of acute myocardial ischemia.

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