Evaluation of mitral inflow in a rat model of aortic stenosis using phase contrast MRI
Kristine Skrdal 1,2 , Emil K. S. Espe 1,2 , Magnus Aronsen 1,2 , Lili Zhang 1,2 , and Ivar Sjaastad 1,2
Institute for Experimental Medical Research,
Oslo University Hospital and University of Oslo, Oslo,
Jebsen Cardiac Research Center and Center for Heart
Failure Research, University of Oslo, Oslo, Oslo, Norway
Assessment of diastolic dysfunction is important in
basic research, involved in studying the mechanisms
behind heart failure with preserved ejection fraction.
However, more optimal methods are needed to study
diastolic function in vivo in small animals. For the
first time, phase contrast MRI (PC-MRI) has been
extended to evaluate mitral inflow in a rat model. We
found that PC-MRI can detect alterations in mitral flow,
showing increased peak flow and deceleration rate of the
mitral flow in response to disease. The results further
advance the potential of PC-MRI as a complete method for
evaluation of diastolic dysfunction in rodents.
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