Optimized threshold selection for automatic carotid intraplaque hemorrhage detection in magnetization-prepared rapid acquisition gradient-echo (MP-RAGE) MRI with histology validation
Jin Liu 1 , Niranjan Balu 1 , Daniel S. Hippe 1 , Marina S. Ferguson 1 , Vanesa Martinez-Malo 1 , J. Kevin DeMarco 2 , David C. Zhu 2 , Hideki Ota 3 , Jie Sun 1 , William S. Kerwin 1 , Thomas S. Hatsukami 1 , and Chun Yuan 1
University of Washington, Seattle, WA,
State University, MI, United States,
University Hospital, Sendai, Japan
Intraplaque hemorrhage (IPH), a critical factor in
atherosclerosis destabilization, can be detected as a
hyperintense area in magnetization-prepared rapid
acquisition gradient-echo (MP-RAGE) MR images. Currently
the threshold to define hyperintensity is arbitrarily
chosen relative to surrounding muscle without histology
validation.. In this study, optimized thresholds for
carotid IPH detection in MP-RAGE images were obtained
using histology as golden standard, providing an
automatic and effective IPH detection method.
Furthermore, results showed that the IPH areas measured
in MRI using the optimized thresholds highly correlated
with those measured in histology.
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