Ultrahigh-field quantitative MR imaging of ex vivo intracranial atherosclerotic plaques
Anita A. Harteveld 1 , Nerissa P. Denswil 2 , Jeroen C.W. Siero 1 , Jaco J.M. Zwanenburg 1,3 , Aryan Vink 4 , Wim G.M. Spliet 4 , Nikki Dieleman 1 , Peter R. Luijten 1 , Mat J.A.P. Daemen 2 , Jeroen Hendrikse 1 , and Anja G. van der Kolk 1
Department of Radiology, University Medical
Center Utrecht, Utrecht, Netherlands,
of Pathology, Academic Medical Center, Amsterdam,
Science Institute, University Medical Center Utrecht,
of Pathology, University Medical Center Utrecht,
Intracranial atherosclerosis is one of the most
important causes of ischemic stroke and transient
ischemic attack (TIA). In the recent years, several
intracranial vessel wall imaging techniques using (ultra)high-field
magnetic resonance imaging (MRI) have emerged for the
evaluation of atherosclerotic vessel wall lesions.
However, a thorough correlation of MRI results of
intracranial plaques with histopathology is still
lacking. Therefore, a multi-contrast
ultrahigh-resolution MRI protocol at 7T was developed
for ex vivo quantitative intracranial atherosclerotic
plaque characterization. Together with the results of
the corresponding histological data, a proper
correlation of the MRI findings with the underlying
pathology may be performed.
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