Abstract #2547
Probing energy metabolism in the ischemic rat heart with hyperpolarized 13C MRS
Hikari A. I. Yoshihara 1,2 , Jessica A. M. Bastiaansen 2,3 , Corinne Berthonneche 4 , Arnaud Comment 2,3 , and Juerg Schwitter 5
1
Division of Cardiology, Lausanne University
Hospital, Lausanne, Switzerland,
2
Center
for Biomedical Imaging (CIBM), Lausanne, Switzerland,
3
Institute
of Physics of Biological Systems, Ecole Polytechnique
Fdrale de Lausanne, Switzerland,
4
Cardiovascular
Assessment Facility, Lausanne University Hospital,
Switzerland,
5
Division
of Cardiology and Cardiac MR Center, Lausanne University
Hospital, Switzerland
An open-chest rat model of myocardial ischemia was
adapted to study in real time, using hyperpolarized 13C
MRS, the changes in cardiac metabolism associated with
short 15 minute periods of ischemia. Immediately
following ischemia, a decrease in the conversion of
infused hyperpolarized pyruvate to bicarbonate was
observed relative to its conversion to lactate,
consistent with the expected decrease in pyruvate
dehydrogenase activity and increase in lactate
concentration. This study establishes an experimental
platform for further studies with other hyperpolarized
13C metabolic probes.
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