Patient Centered Registration and Analysis of Diffusion MRI for Robust Detection of Spatially Varying Microstructural Changes
Asif K Suri 1,2 , Roman Fleysher 1 , and Michael L Lipton 1,3
Albert Einstein College of Medicine, Bronx,
NY, United States,
Psychiatric Center, Bronx, NY, United States,
Medical Center, Bronx, United States
Brain registration of a subject and set of controls to a
template is an essential step in determining diffusion
abnormalities obtained from MR diffusion imaging.
Limitations in the registration process compounded with
use of a canonical brain atlas, results in
misregistrations that can result in erroneous
identification of abnormal diffusion values within
subjects. This study attempts to reduce misregistrations
using subject based template, which increases the
accuracy of registration. This strategy demonstrates a
substantial decrease in volume of abnormally low FA
attributed to the improved accuracy of registration and
can have useful clinical applications.
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