Abstract #2607
Measurement of axon diameter and axon density of the corticospinal tract in idiopathic normal pressure hydrocephalus by q-space imaging
Kouhei Kamiya 1,2 , Masaaki Hori 1 , Yuriko Suzuki 3 , Atsushi Nakanishi 1 , Issei Fukunaga 1 , Koji Kamagata 1 , Mariko Yoshida 1 , Masakazu Miyajima 4 , Hajime Arai 4 , and Shigeki Aoki 1
1
Department of Radiology, Juntendo University
School of Medicine, Bunkyo, Tokyo, Japan,
2
Deparment
of Radiology, Graduate School of Medicine, the
University of Tokyo, Bunkyo, Tokyo, Japan,
3
Philips
Electronics Japan, Ltd, Tokyo, Japan,
4
Department
of Neurosurgery, Juntendo University Graduate School of
Medicine, Bunkyo, Tokyo, Japan
The gait disturbance is a characteristic treatable
symptom of idiopathic normal pressure hydrocephalus (iNPH),
though the etiology is not clear yet. This study
evaluated axon diameter and axon density of the cortico-spinal
tract (CST) in iNPH patients by using two-component
low-q fit method of q-space imaging. Compared with
controls, patients with iNPH had increased axon density
of the CST running near the lateral ventricle, whereas
the axon diameter was not altered. The present results
suggest the idea that the gait disturbance in iNPH is
not due to irreversible axonal damage, but results from
compression and/or stretching of neural tracts.
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