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Abstract #2639

Apparent exchange rate (AXR) mapping in diffusion MRI: An in vivo test-retest study and analysis of statistical power.

Bjrn Lampinen 1 , Filip Szczepankiewicz 1 , Danielle van Westen 2 , Pia Sundgren 2 , Freddy Sthlberg 1,2 , Jimmy Ltt 3 , and Markus Nilsson 4

1 Dpt. of Medical Radiation Physics, Lund University, Lund, Sweden, 2 Dpt. of Diagnostic Radiology, Lund University, Lund, Sweden, 3 Center for Medical Imaging and Physiology, Lund University Hospital, Lund, Sweden, 4 Lund University Bioimaging Center, Lund University, Lund, Sweden

Water exchange can be mapped noninvasively in diffusion MRI using filter-exchange imaging (FEXI) to obtain the apparent exchange rate (AXR). We here aim to prepare FEXI for future clinical research that investigates differences in mean AXR across populations. A test-retest study is conducted on 18 healthy volunteers to assess how inter-subject differences and measurement error contribute to variance in AXR in various brain regions. A power analysis is then performed to interpret AXR variance in terms of study group sizes required to detect a range of differences while ensuring a statistical power of 0.8. We show that with study groups under 10 subjects, mean differences between populations of 40-80% in AXR, depending on the region, can be detected.

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