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Abstract #2648

Quantitative evaluation of biophysical models of the diffusion with in vivo data by assessment of the generalization error

Benoit Scherrer 1 , Maxime Taquet 1 , Mustafa Sahin 2 , Sanjay P Prabhu 1 , and Simon K. Warfield 1

1 Radiology, Harvard Medical School, Boston Children's Hospital, Boston, MA, United States, 2 Neurology, Harvard Medical School, Boston Children's Hospital, Boston, MA, United States

We propose a novel framework to achieve quantitative evaluation of biophysical models of the diffusion with in-vivo data. It enables identification of the model that best predicts the diffusion signal, and therefore identification of the model that best captures the underlying biophysical mechanisms. We investigate the performance of DTI, NODDI and DIAMOND.

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