Age Related Changes in Diffusion Tensor Indices in the Medial and Lateral Gastrocnemius.
Usha Sinha 1 , Robert Csapo 2 , Vadim Malis 1 , Yanjie Xue 1 , and Shantanu Sinha 2
Physics, SDSU, San Diego, CA, United States,
UCSD, San Diego, CA, United States
Age related changes in muscle alter both fiber
architecture (flengths and pennation angles) as well the
microstructure (fiber type, diameter, fibrosis).
Diffusion tensor imaging allows the mapping of fiber
architecture as well as the microstructure. We report
age related changes in diffusion tensor indices (eigenvalues
and FA) of the medial and lateral gastrocnemius in a
cohort of 5 young and 5 old women. All three eigenvalues
for both muscles increase with age, significant
difference in young and old was seen for nearly all the
indices. A decreased fiber diameter and muscle fiber
fraction may qualitatively explain the current findings.
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